ECEL1 May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Belongs to the peptidase M13 family. Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 1|1 C5
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane
Molecular Function:  hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity
Biological Process:  intracellular signal transduction; neuropeptide signaling pathway; proteolysis; respiratory system process
Reference #:  Q9JMI0 (UniProtKB)
Alt. Names/Synonyms: Damage-induced neuronal endopeptidase; Dine; Ecel1; endothelin converting enzyme-like 1; Endothelin-converting enzyme-like 1; Xce; Xce protein
Gene Symbols: Ecel1
Molecular weight: 87,993 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene