DYRK3 a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Expressed primarily in erythroid progenitor cells and regulates late erythropoiesis. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 1|1 E4
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytoskeleton; cytosol; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus; pericentriolar material
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; erythrocyte differentiation; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; nuclear speck organization; organelle disassembly; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cell cycle G2/M phase transition; protein phosphorylation; regulation of cellular response to stress; regulation of TORC1 signaling; stress granule disassembly
Reference #:  Q922Y0 (UniProtKB)
Alt. Names/Synonyms: BC006704; Dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; Dyrk3
Gene Symbols: Dyrk3
Molecular weight: 65,572 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene