HIR Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. Heart, skeletal muscle, and several different brain regions including the hippocampus. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  basolateral plasma membrane; cell junction; cytoplasmic vesicle membrane; plasma membrane; postsynaptic membrane; voltage-gated potassium channel complex
Molecular Function:  PDZ domain binding; protein binding
Biological Process:  cardiac conduction; potassium ion transport; regulation of ion transmembrane transport
Reference #:  P48050 (UniProtKB)
Alt. Names/Synonyms: Hippocampal inward rectifier; hippocampal inward rectifier potassium channel; HIR; HIRK2; HRK1; Inward rectifier K(+) channel Kir2.3; inward rectifier K+ channel Kir2.3; Inward rectifier potassium channel 4; IRK-3; IRK3; IRK4; KCNJ4; Kir2.3; MGC142066; MGC142068; Potassium channel, inwardly rectifying subfamily J member 4; potassium channel, inwardly rectifying subfamily J, member 4; potassium inwardly rectifying channel subfamily J member 4; potassium inwardly-rectifying channel J4; potassium inwardly-rectifying channel, subfamily J, member 4; potassium voltage-gated channel subfamily J member 4
Gene Symbols: KCNJ4
Molecular weight: 49,500 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein