CD84 Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8. Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1 H3|1 79.54 cM
Cellular Component:  integral component of membrane; membrane; plasma membrane
Molecular Function:  identical protein binding
Biological Process:  adaptive immune response; autophagy; cell adhesion; immune system process; innate immune response; negative regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of interleukin-10 secretion; negative regulation of interleukin-18 production; negative regulation of interleukin-6 secretion; negative regulation of mast cell activation; negative regulation of mast cell degranulation; positive regulation of MAPK cascade; positive regulation of monocyte chemotactic protein-1 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of tumor necrosis factor secretion; regulation of lipopolysaccharide-mediated signaling pathway; regulation of macrophage activation; regulation of store-operated calcium entry
Reference #:  Q18PI6 (UniProtKB)
Alt. Names/Synonyms: A130013D22Rik; Cd84; CD84 antigen; CDw84; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; SLAF5; SLAM family member 5; Slamf5
Gene Symbols: Cd84
Molecular weight: 37,378 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
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CD84

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene