p57Kip2
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. Belongs to the CDI family. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor |
Chromosomal Location of human Ortholog: 11p15.4 |
Cellular Component:
cytoplasm; nucleus
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Molecular Function:
cyclin-dependent protein serine/threonine kinase inhibitor activity; molecular function inhibitor activity; protein binding; protein kinase inhibitor activity; protein-containing complex binding
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Biological Process:
adrenal gland development; camera-type eye development; cell cycle; digestive system development; embryonic placenta morphogenesis; genomic imprinting; kidney development; multicellular organism growth; myeloid cell differentiation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription by RNA polymerase II; neuron maturation; positive regulation of DNA-templated transcription; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of exit from mitosis; regulation of lens fiber cell differentiation; skeletal system development; uterus development
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Disease: Beckwith-wiedemann Syndrome; Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
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Reference #:
P49918
(UniProtKB)
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Alt. Names/Synonyms: BWCR; BWS; CDKN1C; CDN1C; cyclin dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; KIP2; p57; p57Kip2; WBS
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Gene Symbols: CDKN1C
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Molecular weight:
32,177 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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