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IL13R
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily. Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of Human Ortholog: Xq24 |
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Cellular Component:
interleukin-13 receptor complex; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
cell surface receptor signaling pathway; cytokine-mediated signaling pathway; interleukin-13-mediated signaling pathway
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Reference #:
P78552
(UniProtKB)
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Alt. Names/Synonyms: bB128O4.2.1 (interleukin 13 receptor, alpha 1); Cancer/testis antigen 19; CD213A1; CD213a1 antigen; CT19; I13R1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13Ra; IL-13RA1; IL13 receptor alpha-1 chain; IL13R; IL13RA; IL13RA1; interleukin 13 receptor subunit alpha 1; interleukin 13 receptor, alpha 1; Interleukin-13 receptor subunit alpha-1; NR4
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Gene Symbols: IL13RA1
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Molecular weight:
48,760 Da
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Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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