GALNT12 an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 4|4 B1
Cellular Component:  Golgi apparatus; integral component of membrane; membrane
Molecular Function:  carbohydrate binding; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups
Reference #:  Q8BGT9 (UniProtKB)
Alt. Names/Synonyms: 9130206E10; A630062B03Rik; galNAc-T12; Galnt12; mpp-GalNAc-T12; OTTMUSP00000007178; polypeptide GalNAc transferase 12; Polypeptide N-acetylgalactosaminyltransferase 12; pp-GaNTase 12; protein-UDP acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12
Gene Symbols: Galnt12
Molecular weight: 66,541 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
Select Structure to View Below

GALNT12

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein