TEAD1
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of human Ortholog: 11p15.3 |
Cellular Component:
chromatin; nucleoplasm; nucleus; TEAD-YAP complex; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
embryonic organ development; hippo signaling; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of transcription by RNA polymerase II
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Disease: Sveinsson Chorioretinal Atrophy
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Reference #:
P28347
(UniProtKB)
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Alt. Names/Synonyms: AA; atrophia areata, peripapillary chorioretinal degeneration; NTEF-1; Protein GT-IIC; REF1; SV40 transcriptional enhancer factor; TCF-13; TCF13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEA domain transcription factor 1; TEAD-1; TEAD1; TEF-1; TEF1; Transcription factor 13; transcriptional enhancer factor 1; Transcriptional enhancer factor TEF-1
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Gene Symbols: TEAD1
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Molecular weight:
47,946 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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