ANXA6 May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Belongs to the annexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 11 B1.3|11 32.13 cM
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; focal adhesion; intercalated disc; late endosome membrane; lysosomal membrane; membrane; nucleus; perinuclear region of cytoplasm; protein-containing complex; sarcolemma
Molecular Function:  actin filament binding; calcium channel activity; calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cholesterol binding; chondroitin sulfate binding; GTP binding; identical protein binding; ligand-gated ion channel activity; lipid binding; phosphatidylserine binding; protein-containing complex binding
Biological Process:  apoptotic signaling pathway; calcium ion transport; growth plate cartilage chondrocyte differentiation; ion transmembrane transport; mitochondrial calcium ion homeostasis; negative regulation of sequestering of calcium ion; neural crest cell migration; plasma membrane repair; regulation of muscle contraction
Reference #:  P14824 (UniProtKB)
Alt. Names/Synonyms: 67 kDa calelectrin; Annexin A6; Annexin VI; annexin VI, p68; Annexin-6; Anx6; Anxa6; AnxVI; AW107198; Cab; Cabm; Calphobindin-II; Cam; Camb; Chromobindin-20; CPB-II; Lipocortin VI; OTTMUSP00000006658; p68; p70; Protein III
Gene Symbols: Anxa6
Molecular weight: 75,885 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene