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ANXA6
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Belongs to the annexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 11 B1.3|11 32.13 cM |
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Cellular Component:
apical plasma membrane; cytoplasm; focal adhesion; intercalated disc; late endosome membrane; lysosomal membrane; membrane; nucleus; perinuclear region of cytoplasm; protein-containing complex; sarcolemma
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Molecular Function:
actin filament binding; calcium channel activity; calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cholesterol binding; chondroitin sulfate binding; GTP binding; ligand-gated ion channel activity; lipid binding; phosphatidylserine binding; protein homodimerization activity; protein-containing complex binding
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Biological Process:
apoptotic signaling pathway; calcium ion transport; growth plate cartilage chondrocyte differentiation; ion transmembrane transport; mitochondrial calcium ion homeostasis; negative regulation of sequestering of calcium ion; neural crest cell migration; plasma membrane repair; protein homooligomerization; regulation of muscle contraction
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Reference #:
P14824
(UniProtKB)
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Alt. Names/Synonyms: 67 kDa calelectrin; Annexin A6; Annexin VI; annexin VI, p68; Annexin-6; Anx6; Anxa6; AnxVI; AW107198; Cab; Cabm; Calphobindin-II; Cam; Camb; Chromobindin-20; CPB-II; Lipocortin VI; OTTMUSP00000006658; p68; p70; Protein III
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Gene Symbols: Anxa6
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Molecular weight:
75,885 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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