BCDIN3 S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. Belongs to the methyltransferase superfamily. Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.; EC 2.1.1.-; Methyltransferase; RNA processing; Transcription regulation
Chromosomal Location of human Ortholog: 7q22.1
Cellular Component: 
Molecular Function:  RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process:  negative regulation of chromatin binding; negative regulation of transcription by RNA polymerase II; positive regulation of G1/S transition of mitotic cell cycle; RNA methylation; snRNA metabolic process; snRNA modification
Reference #:  Q7L2J0 (UniProtKB)
Alt. Names/Synonyms: 7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; MEPCE; methylphosphate capping enzyme
Gene Symbols: MEPCE
Molecular weight: 74,355 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
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BCDIN3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene