BCDIN3 S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. Belongs to the methyltransferase superfamily. Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.; EC 2.1.1.-; Methyltransferase; RNA processing; Transcription regulation
Chromosomal Location of human Ortholog: 7q22.1
Cellular Component:  7SK snRNP; nucleus; ribonucleoprotein complex
Molecular Function:  7SK snRNA binding; O-methyltransferase activity; protein binding; RNA 5'-methyltransferase activity; RNA binding; RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; snRNA binding
Biological Process:  negative regulation of chromatin binding; negative regulation of transcription by RNA polymerase II; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of protein localization to Cajal body; positive regulation of snRNA transcription by RNA polymerase II; RNA methylation; snRNA metabolic process; snRNA modification
Reference #:  Q7L2J0 (UniProtKB)
Alt. Names/Synonyms: 7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; MEPCE; methylphosphate capping enzyme
Gene Symbols: MEPCE
Molecular weight: 74,355 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene