DDX9 a multifunctional ATP-dependent nucleic acid helicase that unwinds double-stranded DNA and RNA in a 3' to 5' direction. Plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression. Belongs to the DEAD box helicase family. DEAH subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component:  actin cytoskeleton; centrosome; CRD-mediated mRNA stability complex; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; micro-ribonucleoprotein complex; nuclear body; nuclear stress granule; nucleoplasm; nucleus; perichromatin fibrils; polysomal ribosome; polysome; protein-containing complex; ribonucleoprotein complex; RISC-loading complex
Molecular Function:  ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent 3'-5' DNA/RNA helicase activity; ATP-dependent 3'-5' RNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; ATPase activity; chromatin DNA binding; DNA binding; DNA replication origin binding; double-stranded DNA binding; double-stranded RNA binding; importin-alpha family protein binding; metal ion binding; mRNA binding; nucleoside-triphosphatase activity; nucleoside-triphosphate diphosphatase activity; polysome binding; promoter-specific chromatin binding; protein binding; regulatory region RNA binding; RISC complex binding; RNA binding; RNA helicase activity; RNA polymerase binding; RNA polymerase II complex binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; RNA stem-loop binding; sequence-specific mRNA binding; single-stranded DNA binding; single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity; single-stranded RNA binding; siRNA binding; transcription coactivator activity; transcription coregulator activity; triplex DNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; cellular response to exogenous dsRNA; cellular response to tumor necrosis factor; CRD-mediated mRNA stabilization; DNA duplex unwinding; DNA replication; DNA-templated transcription, termination; DNA-templated viral transcription; G-quadruplex DNA unwinding; inflammatory response; innate immune response; mRNA splicing, via spliceosome; mRNA transport; positive regulation of cytoplasmic translation; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; positive regulation of fibroblast proliferation; positive regulation of gene silencing by miRNA; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of interferon-alpha secretion; positive regulation of interferon-beta secretion; positive regulation of interleukin-18 production; positive regulation of interleukin-6 secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of polysome binding; positive regulation of response to cytokine stimulus; positive regulation of RNA export from nucleus; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor secretion; positive regulation of type I interferon production; positive regulation of viral transcription; positive regulation of viral translation; protein localization to cytoplasmic stress granule; pyroptosis; regulation of cytoplasmic translation; regulation of defense response to virus by host; regulation of mRNA processing; regulation of transcription by RNA polymerase II; rhythmic process; RNA secondary structure unwinding; small RNA loading onto RISC; targeting of mRNA for destruction involved in RNA interference
Reference #:  Q08211 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase A; DDX9; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box helicase 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; DEAH-box helicase 9; DExH-box helicase 9; DHX9; leukophysin; LKP; NDH II; NDH2; NDHII; Nuclear DNA helicase II; RHA; RNA helicase A
Gene Symbols: DHX9
Molecular weight: 140,958 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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