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MVP
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 16p11.2 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear pore; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; secretory granule lumen
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Molecular Function:
identical protein binding; protein binding; protein kinase binding; protein phosphatase binding
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Biological Process:
ERBB signaling pathway; mRNA transport; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein autophosphorylation; negative regulation of protein tyrosine kinase activity; protein transport
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Reference #:
Q14764
(UniProtKB)
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Alt. Names/Synonyms: LRP; Lung resistance-related protein; Major vault protein; MVP; testicular secretory protein Li 30; VAULT1
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Gene Symbols: MVP
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Molecular weight:
99,327 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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