TRIP13 Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation. Belongs to the AAA ATPase family. PCH2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component:  male germ cell nucleus
Molecular Function:  ATP binding; identical protein binding; protein binding; transcription coregulator activity
Biological Process:  double-strand break repair; female meiosis I; male meiosis I; mitotic spindle assembly checkpoint; oocyte maturation; oogenesis; reciprocal meiotic recombination; regulation of nucleic acid-templated transcription; spermatid development; spermatogenesis; synaptonemal complex assembly; transcription by RNA polymerase II
Disease: Mosaic Variegated Aneuploidy Syndrome 3
Reference #:  Q15645 (UniProtKB)
Alt. Names/Synonyms: 16E1-BP; 16E1BP; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; Human papillomavirus type 16 E1 protein-binding protein; Pachytene checkpoint protein 2 homolog; Thyroid hormone receptor interactor 13; thyroid receptor interacting protein 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13; TRIP13; TRP13
Gene Symbols: TRIP13
Molecular weight: 48,551 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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TRIP13

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB