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TRIP13
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation. Belongs to the AAA ATPase family. PCH2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 5p15.33 |
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Cellular Component:
male germ cell nucleus
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Molecular Function:
ATP binding; identical protein binding; protein binding; transcription coregulator activity
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Biological Process:
double-strand break repair; female meiosis I; male meiosis I; mitotic spindle assembly checkpoint; oocyte maturation; oogenesis; reciprocal meiotic recombination; regulation of nucleic acid-templated transcription; spermatid development; spermatogenesis; synaptonemal complex assembly; transcription by RNA polymerase II
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Disease: Mosaic Variegated Aneuploidy Syndrome 3
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Reference #:
Q15645
(UniProtKB)
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Alt. Names/Synonyms: 16E1-BP; 16E1BP; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; Human papillomavirus type 16 E1 protein-binding protein; Pachytene checkpoint protein 2 homolog; Thyroid hormone receptor interactor 13; thyroid receptor interacting protein 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13; TRIP13; TRP13
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Gene Symbols: TRIP13
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Molecular weight:
48,551 Da
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Basal Isoelectric point:
5.73
Predict pI for various phosphorylation states
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