SSTR2 Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Belongs to the G-protein coupled receptor 1 family. Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  cytosol; neuron projection; plasma membrane
Molecular Function:  G protein-coupled receptor activity; neuropeptide binding; PDZ domain binding; peptide binding; protein binding; somatostatin receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; cerebellum development; forebrain development; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of cell population proliferation; neuropeptide signaling pathway; peristalsis; regulation of muscle contraction; response to starvation; somatostatin signaling pathway; spermatogenesis
Reference #:  P30874 (UniProtKB)
Alt. Names/Synonyms: somatostatin receptor 2; Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R; SSR2; SST2A; SSTR2
Gene Symbols: SSTR2
Molecular weight: 41,333 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene