|
CNR2
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family. Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. Note: This description may include information from UniProtKB.
|
| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 1p36.11 |
|
Cellular Component:
cytoplasm; dendrite; endoplasmic reticulum; extrinsic component of cytoplasmic side of plasma membrane; perikaryon; plasma membrane
|
|
Molecular Function:
cannabinoid receptor activity; protein binding
|
|
Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; cannabinoid signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; immune response; inflammatory response; leukocyte chemotaxis; negative regulation of action potential; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; regulation of metabolic process; response to amphetamine; response to lipopolysaccharide
|
|
Reference #:
P34972
(UniProtKB)
|
|
Alt. Names/Synonyms: Cannabinoid receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2; CB2A; CB2B; CNR2; CX5; hCB2; testis-dominant CNR2 isoform CB2
|
|
Gene Symbols: CNR2
|
|
Molecular weight:
39,681 Da
|
|
Basal Isoelectric point:
8.52
Predict pI for various phosphorylation states
|
