AlphaK3 Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. Highly expressed in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; EC 2.7.11.-; Kinase, protein; Protein kinase, atypical
Chromosomal Location of Human Ortholog: 3|3 G2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; kinase activity; monosaccharide binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cytoplasmic pattern recognition receptor signaling pathway; immune system process; innate immune response; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein phosphorylation; response to bacterium
Reference #:  Q9CXB8 (UniProtKB)
Alt. Names/Synonyms: 8430410J10Rik; alpha-kinase 1; Alpha-protein kinase 1; AlphaK3; Alpk1; Kiaa1527; Lak; lymphocyte alpha-kinase; Lymphocyte alpha-protein kinase
Gene Symbols: Alpk1
Molecular weight: 136,134 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene