mGluR2 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 3p21.2
Cellular Component:  astrocyte projection; axon; dendrite; glutamatergic synapse; plasma membrane; presynaptic membrane
Molecular Function:  adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; calcium channel regulator activity; G protein-coupled receptor activity; glutamate receptor activity; group II metabotropic glutamate receptor activity; protein binding; scaffold protein binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; behavioral response to nicotine; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; gene expression; glutamate homeostasis; glutamate secretion; long-term synaptic depression; negative regulation of adenylate cyclase activity; presynaptic modulation of chemical synaptic transmission; regulation of dopamine secretion; regulation of glutamate secretion; regulation of protein kinase B signaling; regulation of response to drug; regulation of synaptic transmission, glutamatergic; response to cocaine
Reference #:  Q14416 (UniProtKB)
Alt. Names/Synonyms: GLUR2; glutamate metabotropic receptor 2; glutamate receptor homolog; glutamate receptor, metabotropic 2; GPRC1B; GRM2; Metabotropic glutamate receptor 2; mGlu2; MGLUR2
Gene Symbols: GRM2
Molecular weight: 95,568 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein