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EHD1
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. Highly expressed in testis. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Vesicle |
| Chromosomal Location of mouse Ortholog: 19 A|19 4.4 cM |
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Cellular Component:
cell projection; ciliary pocket membrane; cilium; cytoplasm; cytoplasmic vesicle; early endosome; early endosome membrane; endocytic vesicle; endosome; endosome membrane; lipid droplet; membrane; perinuclear region of cytoplasm; plasma membrane; platelet dense tubular network membrane; recycling endosome membrane
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Molecular Function:
ATP binding; calcium ion binding; GTP binding; identical protein binding; metal ion binding; nucleotide binding; protein binding; small GTPase binding
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Biological Process:
cell projection organization; cellular response to nerve growth factor stimulus; cholesterol homeostasis; cilium assembly; endocytic recycling; endocytosis; endosomal transport; intracellular protein transport; low-density lipoprotein particle clearance; neuron projection development; positive regulation of cholesterol storage; positive regulation of endocytic recycling; positive regulation of myoblast fusion; positive regulation of neuron projection development; protein homooligomerization; protein localization to cilium; protein localization to plasma membrane; protein transport
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Reference #:
Q9WVK4
(UniProtKB)
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Alt. Names/Synonyms: AA409636; EH domain-containing protein 1; EH-domain containing 1; Ehd1; mPAST1; OTTMUSP00000020169; PAST homolog 1; Past1; RME-; RME-1
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Gene Symbols: Ehd1
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Molecular weight:
60,603 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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