RASA1 Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 13 C3|13 45.05 cM
Cellular Component:  cytosol; membrane; nuclear membrane; plasma membrane; ruffle
Molecular Function:  GTPase activator activity; GTPase binding; ion channel binding; kinase binding; phosphotyrosine residue binding; platelet-derived growth factor receptor binding; protein binding; protein kinase B binding; protein tyrosine kinase binding; protein-containing complex binding; receptor tyrosine kinase binding; signaling receptor binding; transcription factor binding
Biological Process:  activation of GTPase activity; blood vessel morphogenesis; cellular response to epidermal growth factor stimulus; cellular response to platelet-derived growth factor stimulus; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; regulation of actin filament polymerization; response to drug; signal transduction
Reference #:  E9PYG6 (UniProtKB)
Alt. Names/Synonyms: Gap; GTPase-activating protein; MGC7759; p120-rasGAP; RAS p21 protein activator 1; Rasa; Rasa1; RasGAP
Gene Symbols: Rasa1
Molecular weight: 115,429 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein