|
WAVE1
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Belongs to the SCAR/WAVE family. Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 10 B1|10 22.07 cM |
|
Cellular Component:
anchoring junction; cytoplasm; cytoskeleton; lamellipodium; mitochondrial outer membrane; mitochondrion; postsynapse; protein-containing complex; SCAR complex; synapse
|
|
Molecular Function:
actin binding; Arp2/3 complex binding; protein binding; protein kinase A binding; protein kinase A regulatory subunit binding; small GTPase binding
|
|
Biological Process:
actin cytoskeleton organization; cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; dendritic transport of mitochondrion; lamellipodium morphogenesis; mitochondrion morphogenesis; modification of postsynaptic actin cytoskeleton; neuron projection development; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neurotrophin TRK receptor signaling pathway; Rac protein signal transduction; receptor-mediated endocytosis
|
|
Reference #:
Q8R5H6
(UniProtKB)
|
|
Alt. Names/Synonyms: Actin-binding protein WASF1; AI195380; AI838537; OTTMUSP00000022835; OTTMUSP00000022841; Protein WAVE-1; Scar; WAS protein family, member 1; Wasf1; WASP family 1; WASP family protein member 1; WASP family, member 1; WAVE; WAVE-1; Wave1; Wiskott-Aldrich syndrome protein family member 1
|
|
Gene Symbols: Wasf1
|
|
Molecular weight:
61,509 Da
|
|
Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
