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eplin
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake. Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium. 5 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 15 F1|15 56.13 cM |
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Cellular Component:
actin cytoskeleton; brush border; brush border membrane; cell projection; cleavage furrow; cytoplasm; cytoskeleton; cytosol; focal adhesion; membrane; plasma membrane; ruffle; stress fiber
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Molecular Function:
actin binding; actin filament binding; actin monomer binding; metal ion binding; protein binding
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Biological Process:
actin filament bundle assembly; cell migration; cholesterol homeostasis; cholesterol metabolic process; intestinal cholesterol absorption; lipid metabolic process; negative regulation of actin filament depolymerization; ruffle organization; steroid metabolic process
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Reference #:
Q9ERG0
(UniProtKB)
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Alt. Names/Synonyms: 1110021C24Rik; 3526402A12Rik; D15Ertd366e; Epithelial protein lost in neoplasm; epithelial protein lost in neoplasm-a; epithelial protein lost in neoplasm-b; Eplin; LIM domain and actin binding 1; LIM domain and actin-binding protein 1; Lima1; mEPLIN
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Gene Symbols: Lima1
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Molecular weight:
84,060 Da
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Basal Isoelectric point:
6.18
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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