ZAP Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transferase
Chromosomal Location of mouse Ortholog: 6 B1|6 17.72 cM
Cellular Component:  cytoplasm; cytosol; late endosome; lysosome; nucleus
Molecular Function:  DEAD/H-box RNA helicase binding; identical protein binding; metal ion binding; NAD+ ADP-ribosyltransferase activity; RNA binding
Biological Process:  cellular response to exogenous dsRNA; cellular response to virus; defense response to virus; immune system process; innate immune response; negative regulation of viral genome replication; positive regulation of ATPase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of mRNA catabolic process; positive regulation of RIG-I signaling pathway; positive regulation of type I interferon production; regulation of defense response to virus by host; response to virus
Reference #:  Q3UPF5 (UniProtKB)
Alt. Names/Synonyms: 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; D6Bwg1452e; Inactive Poly [ADP-ribose] polymerase 13; OTTMUSP00000027859; PARP13; ZAP; Zc3hav1; ZCCHV; zinc finger CCCH type, antiviral 1; Zinc finger CCCH-type antiviral protein 1
Gene Symbols: Zc3hav1
Molecular weight: 106,688 Da
Basal Isoelectric point: 8.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene