MGRN1 E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16 A1|16 2.48 cM
Cellular Component:  cytoplasm; early endosome; endosome; membrane; nucleus; plasma membrane
Molecular Function:  metal ion binding; protein binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  endosome to lysosome transport; negative regulation of cAMP-mediated signaling; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of smoothened signaling pathway; protein monoubiquitination; protein polyubiquitination; protein ubiquitination
Reference #:  Q9D074 (UniProtKB)
Alt. Names/Synonyms: 2610042J20Rik; E3 ubiquitin-protein ligase MGRN1; Kiaa0544; mahoganoid; Mahogunin RING finger protein 1; mahogunin, ring finger 1; md; Mgrn1; mKIAA0544; N28182; nc; Probable E3 ubiquitin-protein ligase MGRN1; RING-type E3 ubiquitin transferase MGRN1
Gene Symbols: Mgrn1
Molecular weight: 58,477 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene