Rin1 Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351. Expressed in all tissues examined with high levels in brain, placenta and pancreas. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; cytoskeleton; dendrite; membrane; neuronal cell body; plasma membrane
Molecular Function:  GTPase activator activity; protein binding; Ras GTPase binding
Biological Process:  associative learning; endocytosis; memory; negative regulation of synaptic plasticity; signal transduction
Reference #:  Q921Q7 (UniProtKB)
Alt. Names/Synonyms: Ras and Rab interactor 1; Ras interaction/interference protein 1; Rin1
Gene Symbols: Rin1
Molecular weight: 83,014 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene