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SNX9
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of mouse Ortholog: 17 A1|17 3.51 cM |
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Cellular Component:
cell projection; clathrin-coated pit; clathrin-coated vesicle; cuticular plate; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; Golgi apparatus; membrane; plasma membrane; presynapse; trans-Golgi network
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Molecular Function:
1-phosphatidylinositol binding; Arp2/3 complex binding; identical protein binding; lipid binding; phosphatidylinositol binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding
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Biological Process:
cell cycle; cell division; cleavage furrow formation; endocytosis; endosomal transport; intracellular protein transport; lipid tube assembly; mitotic cell cycle; mitotic cytokinesis; plasma membrane tubulation; positive regulation of actin filament polymerization; positive regulation of GTPase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase activity; protein transport; protein-containing complex assembly; receptor-mediated endocytosis; regulation of synaptic vesicle endocytosis
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Reference #:
Q91VH2
(UniProtKB)
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Alt. Names/Synonyms: 2700073N08Rik; SDP1; SH3P; SH3PX1; Snx9; sorting nexin 9; Sorting nexin-9
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Gene Symbols: Snx9
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Molecular weight:
66,546 Da
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Basal Isoelectric point:
5.35
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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