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SLC39A6
May act as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 18|18 A2 |
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Cellular Component:
endoplasmic reticulum; lamellipodium membrane; membrane; membrane raft; plasma membrane
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Molecular Function:
metal ion transmembrane transporter activity; monoatomic cation:bicarbonate symporter activity; protein binding; zinc ion transmembrane transporter activity
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Biological Process:
epithelial to mesenchymal transition; intracellular zinc ion homeostasis; lymphocyte activation; metal ion transport; monoatomic ion transport; T cell receptor signaling pathway; transmembrane transport; zinc ion import across plasma membrane; zinc ion transmembrane transport; zinc ion transport
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Reference #:
Q8C145
(UniProtKB)
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Alt. Names/Synonyms: endoplasmic reticulum membrane protein; Endoplasmic reticulum membrane-linked protein; Erm; Ermelin; S39A6; Slc39a6; solute carrier family 39 (metal ion transporter), member 6; Solute carrier family 39 member 6; Zinc transporter ZIP6; ZIP-6; Zip6; Zrt- and Irt-like protein 6
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Gene Symbols: Slc39a6
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Molecular weight:
86,380 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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