PHLDB2 Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of mouse Ortholog: 16|16 B5
Cellular Component:  basal cortex; cell leading edge; cytoplasm; cytosol; focal adhesion; intermediate filament cytoskeleton; membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  cell migration; establishment of cell polarity; establishment of protein localization; microtubule cytoskeleton organization; negative regulation of focal adhesion assembly; negative regulation of stress fiber assembly; negative regulation of wound healing, spreading of epidermal cells; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; regulation of epithelial to mesenchymal transition; regulation of gastrulation; regulation of microtubule cytoskeleton organization
Reference #:  Q8K1N2 (UniProtKB)
Alt. Names/Synonyms: AV253284; C820004H04Rik; Ll5b; LL5beta; OTTMUSP00000029653; PHLB2; Phldb2; pleckstrin homology like domain, family B, member 2; Pleckstrin homology-like domain family B member 2; pleckstrin homology-like domain, family B, member 2; Protein LL5-beta
Gene Symbols: Phldb2
Molecular weight: 141,486 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

PHLDB2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene