tensin 2 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; EC 3.1.3.-; Phosphatase
Chromosomal Location of Human Ortholog: 15 F2|15 57.29 cM
Cellular Component:  cell junction; focal adhesion; membrane; plasma membrane
Molecular Function:  hydrolase activity; kinase binding; metal ion binding; phosphoprotein phosphatase activity; protein kinase binding; signaling receptor binding
Biological Process:  cellular homeostasis; collagen metabolic process; intracellular signal transduction; kidney development; multicellular organism growth; multicellular organismal homeostasis; negative regulation of cell proliferation; response to muscle activity
Reference #:  Q8CGB6 (UniProtKB)
Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin homolog; C1 domain-containing phosphatase and tensin-like protein; C1-TEN; nep; nph; Tenc1; tensin 2; tensin like C1 domain-containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; Tns2
Gene Symbols: Tenc1
Molecular weight: 152,013 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

tensin 2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene