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RND1
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Belongs to the small GTPase superfamily. Rho family. Mostly expressed in brain and liver. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho |
| Chromosomal Location of mouse Ortholog: 15|15 F1 |
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Cellular Component:
actin cytoskeleton; adherens junction; cytoplasm; cytoskeleton; cytosol; intracellular membrane-bounded organelle; membrane; plasma membrane
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Molecular Function:
GTP binding; GTPase activity; nucleotide binding; protein kinase binding; signaling receptor binding
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Biological Process:
actin filament organization; cell migration; negative regulation of cell adhesion; neuron remodeling; signal transduction; small GTPase mediated signal transduction
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Reference #:
Q8BLR7
(UniProtKB)
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Alt. Names/Synonyms: A830014L09Rik; Arhs; Rho family GTPase 1; Rho-related GTP-binding protein Rho6; Rho6; Rnd1
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Gene Symbols: Rnd1
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Molecular weight:
26,034 Da
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Basal Isoelectric point:
7.96
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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