RND1 Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Belongs to the small GTPase superfamily. Rho family. Mostly expressed in brain and liver. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho
Chromosomal Location of mouse Ortholog: 15|15 F1
Cellular Component:  actin cytoskeleton; adherens junction; cell cortex; cell division site; cytoplasm; cytoskeleton; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein kinase binding; signaling receptor binding
Biological Process:  actin filament bundle assembly; actin filament organization; establishment or maintenance of actin cytoskeleton polarity; negative regulation of cell adhesion; neuron remodeling; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of cell shape; Rho protein signal transduction; small GTPase mediated signal transduction
Reference #:  Q8BLR7 (UniProtKB)
Alt. Names/Synonyms: A830014L09Rik; Arhs; Rho family GTPase 1; Rho-related GTP-binding protein Rho6; Rho6; Rnd1
Gene Symbols: Rnd1
Molecular weight: 26,034 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene