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CD99L2
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation. Belongs to the CD99 family. Expressed in many tissues, with low expression in thymus. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: X|X A7.3 |
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Cellular Component:
adherens junction; anchoring junction; cell surface; extracellular region; membrane; plasma membrane
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Biological Process:
cell adhesion; diapedesis; positive regulation of neutrophil extravasation; positive regulation of T cell extravasation
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Reference #:
Q8BIF0
(UniProtKB)
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Alt. Names/Synonyms: AW548191; C99L2; CD99; CD99 antigen-like 2; CD99 antigen-like protein 2; Cd99l2; Mic2; MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1; MIC2 like-1; MIC2-like protein 1; Mic2l1; OTTMUSP00000019527; Xap89
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Gene Symbols: Cd99l2
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Molecular weight:
25,463 Da
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Basal Isoelectric point:
4.71
Predict pI for various phosphorylation states
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