SH3PXD2B Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Belongs to the SH3PXD2 family. Expressed in fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 11|11 A4
Cellular Component:  cell junction; cell projection; cytoplasm; podosome
Molecular Function:  phosphatidylinositol binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; SH2 domain binding; superoxide-generating NADPH oxidase activator activity
Biological Process:  adipose tissue development; bone development; cell differentiation; cranial skeletal system development; extracellular matrix disassembly; eye development; heart development; osteoblast fate commitment; podosome assembly; positive regulation of adipose tissue development; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of stress fiber assembly; protein localization to membrane; regulation of brood size; skeletal system development; skeletal system morphogenesis; superoxide metabolic process
Reference #:  A2AAY5 (UniProtKB)
Alt. Names/Synonyms: Factor for adipocyte differentiation 49; Fad4; Fad49; G431001E03Rik; OTTMUSP00000005550; SH3 and PX domain-containing protein 2B; SH3 and PX domains 2B; Sh3pxd2b; similar to KIAA0418; SPD2B; Tks; Tks4; TSK4; Tyrosine kinase substrate with four SH3 domains
Gene Symbols: Sh3pxd2b
Molecular weight: 101,517 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
Select Structure to View Below

SH3PXD2B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene