ELMO2 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2|2 H3
Cellular Component:  cytoplasm; cytosol; membrane
Molecular Function:  receptor tyrosine kinase binding; SH3 domain binding
Biological Process:  apoptotic process; cell chemotaxis; cell migration; cell-cell adhesion; cytoskeleton organization; phagocytosis
Reference #:  Q8BHL5 (UniProtKB)
Alt. Names/Synonyms: 1190002F24Rik; CED-12; CED-12 homolog A; Elmo2; engulfment and cell motility 2, ced-12 homolog (C. elegans); Engulfment and cell motility protein 2; Kiaa1834; mKIAA1834; OTTMUSP00000001119; OTTMUSP00000001120; OTTMUSP00000001122; OTTMUSP00000017933; OTTMUSP00000017935; Protein ced-12 homolog A
Gene Symbols: Elmo2
Molecular weight: 83,887 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below

ELMO2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene