RAIG1 Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. Belongs to the G-protein coupled receptor 3 family. Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6|6 G1
Cellular Component:  extracellular exosome; integral component of membrane; intracellular membrane-bounded organelle; membrane; nucleolus; plasma membrane; receptor complex; vesicle
Molecular Function:  G protein-coupled receptor activity; protein binding; protein kinase activator activity
Biological Process:  G protein-coupled receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; signal transduction
Reference #:  Q8BHL4 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor, family C, group 5, member A; G-protein coupled receptor family C group 5 member A; Gprc5a; OTTMUSP00000026736; Rai3; RAIG-1; Raig1; retinoic acid induced 3; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3
Gene Symbols: Gprc5a
Molecular weight: 40,101 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene