FLNB Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. Belongs to the filamin family. Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14|14 A1
Cellular Component:  brush border; cytoplasm; cytoskeleton; cytosol; focal adhesion; neuron projection; neuronal cell body; nucleus; phagocytic vesicle; plasma membrane; stress fiber
Molecular Function:  actin binding; identical protein binding; protein binding
Biological Process:  actin cytoskeleton organization; cell differentiation; cellular response to interferon-gamma; epithelial cell morphogenesis; keratinocyte development; skeletal muscle tissue development
Reference #:  Q80X90 (UniProtKB)
Alt. Names/Synonyms: ABP-280-like protein; actin binding protein 278; Actin-binding-like protein; AL024016; Beta-filamin; filamin, beta; Filamin-B; FLN-B; Flnb
Gene Symbols: Flnb
Molecular weight: 277,825 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FLNB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene