SEC31A Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 5|5 E4
Cellular Component:  COPII vesicle coat; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; endosome; intracellular membrane-bounded organelle; perinuclear region of cytoplasm; vesicle coat
Molecular Function:  calcium-dependent protein binding; structural molecule activity
Biological Process:  cargo loading into COPII-coated vesicle; COPII-coated vesicle budding; endoplasmic reticulum organization; ER to Golgi vesicle-mediated transport; intracellular protein transport; protein transport; response to calcium ion; vesicle-mediated transport
Reference #:  Q3UPL0 (UniProtKB)
Alt. Names/Synonyms: 1810024J13Rik; ABP125; ABP130; AU042160; HSPC275; Protein transport protein Sec31A; SC31A; Sec31 homolog A (S. cerevisiae); SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; Sec31a; Sec31l1
Gene Symbols: Sec31a
Molecular weight: 133,569 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene