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PTPRD
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine |
| Chromosomal Location of mouse Ortholog: 4 C3|4 36.94 cM |
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Cellular Component:
glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
cell adhesion molecule binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; signaling receptor binding
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Biological Process:
dephosphorylation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; modulation of chemical synaptic transmission; negative regulation of receptor signaling pathway via JAK-STAT; neuron differentiation; positive regulation of dendrite morphogenesis; positive regulation of synapse assembly; presynapse assembly; presynaptic membrane assembly; protein dephosphorylation; regulation of immune response; regulation of postsynaptic density assembly; synaptic membrane adhesion; trans-synaptic signaling; trans-synaptic signaling by trans-synaptic complex
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Reference #:
Q64487
(UniProtKB)
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Alt. Names/Synonyms: 1110002J03Rik; 3000002J10Rik; B230219D21Rik; MGC113757; MGC36851; OTTMUSP00000000348; protein tyrosine phosphatase, receptor type, D; Protein-tyrosine phosphatase delta; Ptprd; R-PTP-delta; Receptor-type tyrosine-protein phosphatase delta
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Gene Symbols: Ptprd
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Molecular weight:
214,410 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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