PTPRD Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of mouse Ortholog: 4 C3|4 36.94 cM
Cellular Component:  glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of presynaptic membrane; membrane; Schaffer collateral - CA1 synapse
Molecular Function:  cell adhesion molecule binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; signaling receptor binding
Biological Process:  dephosphorylation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; modulation of chemical synaptic transmission; negative regulation of JAK-STAT cascade; neuron differentiation; positive regulation of dendrite morphogenesis; positive regulation of synapse assembly; presynaptic membrane assembly; protein dephosphorylation; regulation of immune response; regulation of postsynaptic density assembly; synaptic membrane adhesion
Reference #:  Q64487 (UniProtKB)
Alt. Names/Synonyms: 1110002J03Rik; 3000002J10Rik; B230219D21Rik; MGC113757; MGC36851; OTTMUSP00000000348; protein tyrosine phosphatase, receptor type, D; Protein-tyrosine phosphatase delta; Ptprd; R-PTP-delta; Receptor-type tyrosine-protein phosphatase delta
Gene Symbols: Ptprd
Molecular weight: 214,410 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene