PIK3R3 Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Belongs to the PI3K p85 subunit family. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of mouse Ortholog: 4|4 D1

Cellular Component: phosphatidylinositol 3-kinase complex

Molecular Function: 1-phosphatidylinositol-3-kinase regulator activity; phosphotyrosine residue binding; protein binding

Biological Process: cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of gene expression; positive regulation of protein phosphorylation; protein kinase B signaling; regulation of phosphatidylinositol 3-kinase activity

Reference #: Q64143 (UniProtKB)

Alt. Names/Synonyms: AA414954; OTTMUSP00000009799; p55; P55G; p55PIK; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase regulatory subunit 3; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; Pik3r3; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p55-gamma

Gene Symbols: Pik3r3

Molecular weight: 54,474 Da

Basal Isoelectric point: 5.68 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PIK3R3