endophilin A2 Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Vesicle
Chromosomal Location of mouse Ortholog: 17 D|17 29.11 cM
Cellular Component:  cell junction; cell projection; cytoplasm; cytosol; endosome; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; postsynaptic density, intracellular component; presynapse; Schaffer collateral - CA1 synapse; synapse
Molecular Function:  beta-1 adrenergic receptor binding; GTPase binding; identical protein binding; lipid binding; phosphatase binding; protein binding; protein C-terminus binding; SH3 domain binding; transmembrane transporter binding
Biological Process:  endocytosis; modulation of excitatory postsynaptic potential; positive regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle endocytosis; synaptic vesicle uncoating
Reference #:  Q62419 (UniProtKB)
Alt. Names/Synonyms: C77078; EEN; endophilin A2; endophilin II; Endophilin-2; Endophilin-A2; SH3; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; Sh3d2; Sh3d2b; SH3G1; Sh3gl1; SH3p8
Gene Symbols: Sh3gl1
Molecular weight: 41,518 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Select Structure to View Below

endophilin A2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene