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endophilin A2
Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Oncoprotein; Vesicle |
| Chromosomal Location of mouse Ortholog: 17 D|17 29.11 cM |
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Cellular Component:
cell junction; cell projection; cytoplasm; cytosol; endosome; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; postsynaptic density, intracellular component; presynapse; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
beta-1 adrenergic receptor binding; GTPase binding; identical protein binding; lipid binding; phosphatase binding; protein binding; protein C-terminus binding; SH3 domain binding; transmembrane transporter binding
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Biological Process:
endocytosis; modulation of excitatory postsynaptic potential; positive regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle endocytosis; synaptic vesicle uncoating
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Reference #:
Q62419
(UniProtKB)
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Alt. Names/Synonyms: C77078; EEN; endophilin A2; endophilin II; Endophilin-2; Endophilin-A2; SH3; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; Sh3d2; Sh3d2b; SH3G1; Sh3gl1; SH3p8
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Gene Symbols: Sh3gl1
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Molecular weight:
41,518 Da
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Basal Isoelectric point:
5.53
Predict pI for various phosphorylation states
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