GDI2 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Belongs to the Rab GDI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 13|13 A1
Cellular Component:  cytoplasm; Golgi apparatus; membrane; synapse
Molecular Function:  GDP-dissociation inhibitor activity; protein binding; Rab GDP-dissociation inhibitor activity; Rab GTPase binding; small GTPase binding
Biological Process:  protein transport; small GTPase mediated signal transduction; vesicle-mediated transport
Reference #:  Q61598 (UniProtKB)
Alt. Names/Synonyms: GDI; GDI beta; GDI-; GDI-2; GDI-3; GDI-B; Gdi2; Gdi3; GDIB; guanosine diphosphate (GDP) dissociation inhibitor 2; guanosine diphosphate (GDP) dissociation inhibitor 3; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta; Rab GDP dissociation inhibitor beta; RAB GDP dissociation inhibitor beta-2
Gene Symbols: Gdi2
Molecular weight: 50,537 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene