FXR1 RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Belongs to the FMR1 family. Expressed in all tissues examined including heart, brain, kidney and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 3|3 A3
Cellular Component:  axon; costamere; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendrite; dendritic spine; glutamatergic synapse; neuronal cell body; nucleus; perinuclear region of cytoplasm; polysome; postsynapse; postsynaptic density; ribonucleoprotein granule
Molecular Function:  G-quadruplex RNA binding; mRNA 3'-UTR binding; mRNA binding; nucleic acid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; RNA strand annealing activity; translation regulator activity
Biological Process:  cell differentiation; multicellular organism development; muscle organ development; negative regulation of translation; positive regulation of gene silencing by miRNA; positive regulation of translation; regulation of mRNA stability; regulation of translation
Reference #:  Q61584 (UniProtKB)
Alt. Names/Synonyms: 1110050J02Rik; 9530073J07Rik; AI851072; fragile X mental retardation gene 1, autosomal homolog; fragile X mental retardation gene, autosomal homolog; Fragile X mental retardation syndrome-related protein 1; fragile X mental retardation-related protein 1; fragile-X-related protein 1; Fxr1; Fxr1h; Fxr1p; mFxr1p
Gene Symbols: Fxr1
Molecular weight: 76,222 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FXR1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene