Fer iso4 Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 17|17 E1.1
Cellular Component:  cell projection; cytoplasm; cytoskeleton; cytosol; extrinsic component of cytoplasmic side of plasma membrane; membrane; nucleus; plasma membrane
Molecular Function:  actin binding; ATP binding; cadherin binding; cell adhesion molecule binding; cytoskeletal protein binding; epidermal growth factor receptor binding; gamma-catenin binding; kinase activity; lipid binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase 1 binding; protein tyrosine kinase activity; Rab GTPase binding; transferase activity
Biological Process:  actin cytoskeleton reorganization; cell adhesion; cell proliferation; cell-cell adhesion mediated by cadherin; cellular response to insulin stimulus; cellular response to macrophage colony-stimulating factor stimulus; cellular response to reactive oxygen species; chemotaxis; cytokine-mediated signaling pathway; diapedesis; extracellular matrix-cell signaling; Fc-epsilon receptor signaling pathway; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; interleukin-6-mediated signaling pathway; Kit signaling pathway; microtubule cytoskeleton organization; mitotic cell cycle; negative regulation of mast cell activation involved in immune response; peptidyl-tyrosine phosphorylation; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of cell proliferation; regulation of epidermal growth factor receptor signaling pathway; regulation of fibroblast migration; regulation of lamellipodium assembly; regulation of mast cell degranulation; regulation of protein phosphorylation; response to lipopolysaccharide; response to platelet-derived growth factor; signal transduction; substrate adhesion-dependent cell spreading; tyrosine phosphorylation of STAT protein
Reference #:  P70451-4 (UniProtKB)
Alt. Names/Synonyms: AV082135; C330004K01Rik; Fer; fer (fms/fps related) protein kinase; fer (fms/fps related) protein kinase, testis specific 2; Fer iso4; Fert; Fert2; p94-Fer; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; Tyrosine kinase (ferT); Tyrosine-protein kinase Fer
Gene Symbols: Fert2
Molecular weight: 51,601 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

Fer iso4

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene