|
PVR
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. Belongs to the nectin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 7 A3|7 9.95 cM |
|
Cellular Component:
adherens junction; cell surface; membrane; plasma membrane
|
|
Molecular Function:
cell adhesion molecule binding; dynein light chain binding; protein binding; virus receptor activity
|
|
Biological Process:
cell migration; cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; susceptibility to natural killer cell mediated cytotoxicity; susceptibility to T cell mediated cytotoxicity
|
|
Reference #:
Q60977
(UniProtKB)
|
|
Alt. Names/Synonyms: 3830421F03Rik; CD155; D7Ertd458; D7Ertd458e; HVED; mE4; necl; necl-5; poliovirus receptor; Pvr; PVS; Taa1; Tage; Tage4; tumor-associated antigen 1; Tumor-associated glycoprotein E4
|
|
Gene Symbols: Pvr
|
|
Molecular weight:
45,280 Da
|
|
Basal Isoelectric point:
6.83
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
