RASA3 Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of mouse Ortholog: 8 A1.1|8 6.29 cM
Cellular Component:  intrinsic component of the cytoplasmic side of the plasma membrane
Molecular Function:  calcium-release channel activity; GTPase activator activity; metal ion binding
Biological Process:  cellular response to heat; intracellular signal transduction; negative regulation of Ras protein signal transduction; regulation of GTPase activity; signal transduction
Reference #:  Q60790 (UniProtKB)
Alt. Names/Synonyms: AI326412; C86362; E130011G04; GAP1(IP4BP); GapIII; GAPIII activator 3; hlb38; hlb381; Ins P4-binding protein; R-Ras gap; R-ras RTPase activating protein-3; Ras GTPase-activating protein 3; Ras GTPase-activating protein III; RAS p21 protein activator 3; Rasa3; RasGAP 3; scat
Gene Symbols: Rasa3
Molecular weight: 95,987 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene