TIAM1 Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. Belongs to the TIAM family. Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of mouse Ortholog: 16 C3.3|16 51.5 cM
Cellular Component:  axonal growth cone; cell junction; cell-cell contact zone; cell-cell junction; cytoplasm; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of postsynaptic density membrane; glutamatergic synapse; kinocilium; main axon; membrane; neuronal cell body; nucleus; plasma membrane; postsynaptic density; ruffle membrane; somatodendritic compartment; synapse
Molecular Function:  ephrin receptor binding; guanyl-nucleotide exchange factor activity; kinase binding; lipid binding; microtubule binding; phospholipid binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Ras GTPase binding; receptor tyrosine kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  activation of GTPase activity; apoptotic process; brain-derived neurotrophic factor receptor signaling pathway; cardiac muscle hypertrophy; cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; intracellular signal transduction; neuron projection extension; NMDA selective glutamate receptor signaling pathway; positive regulation of axonogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of dendritic spine morphogenesis; positive regulation of JUN kinase activity; positive regulation of neuron projection development; positive regulation of protein binding; positive regulation of Schwann cell chemotaxis; protein localization to membrane; Rac protein signal transduction; regulation of dopaminergic neuron differentiation; regulation of epithelial to mesenchymal transition; regulation of ERK1 and ERK2 cascade; regulation of GTPase activity; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of modification of postsynaptic actin cytoskeleton; regulation of non-canonical Wnt signaling pathway; regulation of Rho protein signal transduction; signal transduction; small GTPase mediated signal transduction
Reference #:  Q60610 (UniProtKB)
Alt. Names/Synonyms: AI847750; D16Ium1; D16Ium10; D16Ium10e; OTTMUSP00000028932; T cell lymphoma invasion and metastasis 1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1; Tiam1
Gene Symbols: Tiam1
Molecular weight: 177,533 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene