EPS8 an adaptor protein that is an epidermal growth factor receptor (EGFR) substrate. Enhances EGF-dependent mitogenic signals. Member of a family of actin barbing and capping proteins. Promotes filopodial protrusions. Complexes containing Eps8/Abi1/PI3K/Sos-1 mediate Rac activation following EGFR signaling. Involved in endocytosis of EGFR by binding to the Rab5-specific GTPase activating protein USP6N. Binds to IRSp53, which binds small the small GTPases Rac and Cdc42, and which regulates actin dynamics. Involved in the actin-remodeling activity in cultured cerebellar neurons. Regulates the actin-remodeling activities of NMDA and ethanol in neurons. Eps8 knockout mice show behavioral resistance to ethanol. Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6 G1|6 66.78 cM
Cellular Component:  brush border; cell cortex; cell junction; cell projection; cytoplasm; glutamatergic synapse; membrane; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; ruffle membrane; stereocilium; stereocilium bundle; stereocilium tip; synapse
Molecular Function:  actin binding; protein binding; Rac GTPase binding; signaling adaptor activity
Biological Process:  actin crosslink formation; actin cytoskeleton reorganization; actin filament bundle assembly; actin polymerization-dependent cell motility; adult locomotory behavior; barbed-end actin filament capping; behavioral response to ethanol; cellular response to leukemia inhibitory factor; dendritic cell migration; exit from mitosis; positive regulation of ruffle assembly; Rac protein signal transduction; regulation of actin filament length; regulation of cell shape; regulation of postsynaptic membrane neurotransmitter receptor levels; regulation of Rho protein signal transduction; Rho protein signal transduction
Reference #:  Q08509 (UniProtKB)
Alt. Names/Synonyms: AW261790; Epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8; Eps8; OTTMUSP00000026105; OTTMUSP00000026106; OTTMUSP00000026108
Gene Symbols: Eps8
Molecular weight: 91,737 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene