Ikaros Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms. Belongs to the Ikaros C2H2-type zinc-finger protein family. Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 11 A1|11 7.02 cM
Cellular Component:  cytoplasm; nuclear pericentric heterochromatin; nucleoplasm; nucleus; pericentric heterochromatin; protein-containing complex; protein-DNA complex; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; nucleic acid binding; poly-pyrimidine tract binding; protein binding; protein domain specific binding; protein heterodimerization activity; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  amacrine cell differentiation; B cell differentiation; cell cycle; chromatin organization; erythrocyte differentiation; establishment of protein localization; forebrain development; gland development; hemopoiesis; lymph node development; lymphocyte differentiation; multicellular organism development; natural killer cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Peyer's patch development; positive regulation of B cell differentiation; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of neutrophil differentiation; positive regulation of NK T cell differentiation; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein heterooligomerization; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; retina development in camera-type eye; retinal bipolar neuron differentiation; T cell differentiation; thymus development
Reference #:  Q03267 (UniProtKB)
Alt. Names/Synonyms: 5832432G11Rik; DNA-binding protein Ikaros; hlk-1; Ikaros; IKAROS family zinc finger 1; Ikaros family zinc finger protein 1; Ikzf1; KIAA4227; LyF-; LyF-1; Lyf1; Lymphoid transcription factor LyF-1; mKIAA4227; OTTMUSP00000005366; RP23-373H2.2; Zfpn; Zfpn1a1; zinc finger protein subfamily 1A, 1; zinc finger protein, subfamily 1A, 1 (Ikaros); Znfn1a1
Gene Symbols: Ikzf1
Molecular weight: 57,336 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene