AKR1B15 Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism. Isoform 2: No oxidoreductase activity observed with the tested substrates. Belongs to the aldo/keto reductase family. Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.-; EC; EC; Oxidoreductase
Chromosomal Location of mouse Ortholog: 6 B1|6 14.91 cM
Cellular Component:  cytoplasm; cytosol; mitochondrion
Molecular Function:  alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; NADP-retinol dehydrogenase activity; oxidoreductase activity; retinal dehydrogenase activity
Biological Process:  cellular detoxification of aldehyde; daunorubicin metabolic process; doxorubicin metabolic process; farnesol catabolic process; oxidation-reduction process; retinoid metabolic process
Reference #:  P45377 (UniProtKB)
Alt. Names/Synonyms: AKR1B15; Akr1b8; ALD2; Aldehyde reductase; aldo-keto reductase family 1, member B8; Aldose reductase-related protein 2; AR; Fgf; Fgfrp; Fgrp; fibroblast growth factor regulated protein; Fibroblast growth factor-regulated protein; FR-1; OTTMUSP00000015663; Protein FR-1
Gene Symbols: Akr1b8
Molecular weight: 36,121 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene