ACTB Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 5 G2|5 81.8 cM
Cellular Component:  actin cytoskeleton; actin filament; adherens junction; apical junction complex; axon; bBAF complex; brahma complex; brush border; calyx of Held; cell-cell junction; chromatin; cortical cytoskeleton; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; GBAF complex; glutamatergic synapse; kinetochore; lamellipodium; membrane; membrane raft; nBAF complex; npBAF complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleosome; nucleus; podosome; postsynaptic actin cytoskeleton; protein-containing complex; ribonucleoprotein complex; RSC-type complex; Schaffer collateral - CA1 synapse; stress fiber; SWI/SNF complex; synapse; tight junction
Molecular Function:  ATP binding; hydrolase activity; identical protein binding; kinesin binding; nitric-oxide synthase binding; nucleotide binding; protein binding; protein kinase binding; structural constituent of postsynaptic actin cytoskeleton; Tat protein binding
Biological Process:  adherens junction assembly; apical protein localization; axonogenesis; cell motility; cellular response to cytochalasin B; cellular response to electrical stimulus; chromatin remodeling; establishment or maintenance of cell polarity; histone acetylation; histone H2A acetylation; histone H4 acetylation; morphogenesis of a polarized epithelium; negative regulation of cell differentiation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of protein binding; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of double-strand break repair via homologous recombination; positive regulation of myoblast differentiation; positive regulation of stem cell population maintenance; positive regulation of T cell differentiation; postsynaptic actin cytoskeleton organization; protein localization to adherens junction; regulation of apoptotic process; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of double-strand break repair; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of norepinephrine uptake; regulation of nucleotide-excision repair; regulation of protein localization to plasma membrane; regulation of synaptic vesicle endocytosis; regulation of transcription by RNA polymerase II; regulation of transepithelial transport; regulation of transmembrane transporter activity
Reference #:  P60710 (UniProtKB)
Alt. Names/Synonyms: A-X actin-like protein; Act; Actb; actin, beta; actin, beta, cytoplasmic; Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed; Actx; beta-a; beta-actin; E430023M04Rik; melanoma X-actin
Gene Symbols: Actb
Molecular weight: 41,737 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein