PTPRE Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). 3 alternative promoter and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 7 F3|7 81.27 cM
Cellular Component:  cytoplasm; integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function:  hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein homodimerization activity; protein tyrosine phosphatase activity
Biological Process:  dephosphorylation; negative regulation of insulin receptor signaling pathway; protein dephosphorylation; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  P49446 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase, receptor type, E; Protein-tyrosine phosphatase epsilon; Ptpe; PTPepsilon; Ptpre; R-PTP-epsilon; Receptor-type tyrosine-protein phosphatase epsilon; RPTPepsilon
Gene Symbols: Ptpre
Molecular weight: 80,688 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene