CACNA1C Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. 26 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component:  cell junction; cytoplasm; dendrite; integral component of membrane; integral component of plasma membrane; L-type voltage-gated calcium channel complex; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; voltage-gated calcium channel complex; Z disc
Molecular Function:  alpha-actinin binding; calmodulin binding; high voltage-gated calcium channel activity; metal ion binding; protein binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in cardiac muscle cell action potential
Biological Process:  calcium ion transmembrane transport; calcium ion transmembrane transport via high voltage-gated calcium channel; calcium ion transport into cytosol; calcium-mediated signaling using extracellular calcium source; camera-type eye development; cardiac conduction; cardiac muscle cell action potential involved in contraction; cell communication by electrical coupling involved in cardiac conduction; embryonic forelimb morphogenesis; heart development; immune system development; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; membrane depolarization during cardiac muscle cell action potential; positive regulation of adenylate cyclase activity; positive regulation of cytosolic calcium ion concentration; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of insulin secretion; regulation of ventricular cardiac muscle cell action potential
Disease: Brugada Syndrome 3; Long Qt Syndrome 8; Timothy Syndrome
Reference #:  Q13936 (UniProtKB)
Alt. Names/Synonyms: CAC1C; CACH2; CACN2; CACNA1C; CACNL1A1; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium voltage-gated channel subunit alpha1 C; CaV1.2; CCHL1A1; DHPR, alpha-1 subunit; LQT8; MGC120730; TS; TS. LQT8; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel alpha subunit Cav1.2; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
Gene Symbols: CACNA1C
Molecular weight: 248,977 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB